Blar i forfatter "Jakobsen, Lotte"
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Dissemination and Characteristics of a Novel Plasmid-Encoded Carbapenem-Hydrolyzing Class D β-Lactamase, OXA-436, Found in Isolates from Four Patients Involving Six Different Hospitals in Denmark.
Samuelsen, Ørjan; Hansen, Frank; Aasnæs, Bettina; Hasman, Henrik; Lund, Bjarte Aarmo; Leiros, Hanna-Kirsti S.; Lilje, Berit; Janice, Jessin; Jakobsen, Lotte; Littauer, Pia; Søes, Lillian M; Holzknecht, Barbara J.; Andersen, Leif P; Stegger, Marc; Andersen, Paal S.; Hammerum, Anette M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-10-23)The diversity of OXA-48-like carbapenemases are continually expanding. In this study, we describe the dissemination and characteristics of a novel class D carbapenemase (CHDL) named OXA-436. In total, six OXA-436-producing Enterobacteriaceae isolates including Enterobacter asburiae (n=3), Citrobacter freundii (n=2) and Klebsiella pneumoniae (n=1) were identified in four patients in the period between ... -
Pharmacokinetics and pharmacodynamics of fosfomycin and its activity against extended-spectrum-lactamase-, plasmid-mediated AmpC-, and carbapenemase-producing escherichia coli in a murine urinary tract infection model
Zykov, Ilya Nikolaevich; Samuelsen, Ørjan; Jakobsen, Lotte; Småbrekke, Lars; Andersson, Dan I.; Sundsfjord, Arnfinn; Frimodt-Møller, Niels (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-25)Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug resistance (MDR) in <i>Escherichia coli</i>. In this study, we evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) indices of fosfomycin and its <i>in vivo</i> activity in an experimental murine model of ascending UTI. Subcutaneous administration of fosfomycin showed that ...